Abstract: Taking a gold-bearing copper-sulfur ore as the research object，on the basis of detailed process mineralogy research，the flotation process of copper preferential flotation followed by sulfur flota‐ tion was applied under low alkalinity conditions. At the same time，the combined inhibitor of lime + pyrite inhibitor code 8395 was used for copper-sulfur separation in the first stage of copper concentrate. The amount of lime in the first stage of copper concentrate was reduced from 300 g/t to 150 g/t，and the pH val‐ ue was reduced from 11.5 to 10. The copper concentrate with copper content of 18.12% and recovery rate of 90.38%，gold content of 2.68 g/t and recovery rate of 54.80% can be obtained. The closed-circuit test index of sulfur concentrate with sulfur content of 47.86% and recovery rate of 42.93%. Compared with the process of single lime in the first stage of copper cleaning，the recovery rate of gold increased by 2.53 per‐ centage points under the condition of equivalent copper and sulfur indexes，and the effective recovery of copper，gold and sulfur under low alkalinity conditions was realized.

Key words: gold-bearing copper-sulfur ore, low alkalinity, copper and sulfur separation, combined in‐ hibitor