Abstract: Aiming at the problems of slow overflow of concentrate foam，poor effect of reagent and high unit consumption in the oxidation section of high oxidation rate copper-cobalt ore of SICOMINES in Congo (DRC) when using overflow flotation machine，the process flow optimization of the system was stud‐ ied. By increasing the dosage of collector and foaming agent in the oxidation section to accelerate the over‐ flow of mineralized foam，and adding desliming flotation process to the copper sulfide flotation tailings， the flotation environment is effectively improved. After optimization，the recovery rates of total copper and total cobalt in the oxidation section are increased by 2.82 and 3.76 percentage points respectively，and the dosage of vulcanizing agent is reduced by 17.21%. The flotation index is significantly improved and the cost of reagents is saved，which can provide reference for the development and utilization of this kind of re‐ sources.

Key words: high oxidation rate copper-cobalt ore, overflow flotation machine, flotation, process optimi‐ zation