Abstract: In order to further improve the convenience and selectivity of quantitative detection tech⁃ nology of major and minor elements in molybdenum concentrate，aiming at molybdenum，copper，iron，sil⁃ icon，lead，calcium and other elements in molybdenum concentrate，X-ray fluorescence spectrometry in⁃ ternal standard method was used to study the technical problems such as instrument working conditions， standard curve making，sample weight determination，oxidant selection，flux selection and internal stan⁃ dard element addition. The accuracy and precision of the method were verified，and the technical method of one-time quantitative determination of major and minor elements in molybdenum concentrate by X-ray fluorescence spectrometry internal standard method was systematically established. The results show that the precision of this method for the determination of molybdenum，copper，iron，silicon，lead and calcium in molybdenum concentrate is 0.14%，2.39%，0.86%，0.47%，0.91% and 0.65%，respectively. The meth⁃ od is convenient and the test results are reliable.

Key words: X-ray fluorescence spectrometry, molybdenum concentrate, glass fusing, internal standard method