Abstract: In order to promote the application and promotion of advanced oxidation technology in sulfide ore flotation，in view of the problems that most of the sulfide ore that can be used for mining at this stage are poor and complicated，the rich ore of easy-to-separate sulfide ore is gradually reduced，the flotation separation efficiency is low，the flotation concentrate grade is low and the recovery rate is not ideal， the mechanism of ozone oxidation，Fenton oxidation and electrochemical catalytic oxidation of advanced oxidation technology and the application status and mechanism of three oxidation technologies in sulfide ore separation process are reviewed. Advanced oxidation technology can produce strong oxidizing hydroxyl radicals，sulfate radicals and superoxide radicals，so that the surface of sulfide ore can produce new substances due to oxidation，which can change the hydrophilicity and hydrophobicity of mineral surface and affect the interaction between minerals and collectors. By summarizing the application of advanced oxidation technology in sulfide ore flotation at present，it is found that controlling the oxidation process to regulate the surface properties of minerals can be used as a new idea to realize the separation of useful minerals and gangue minerals in sulfide ore.

Key words: sulphide ore, flotation, surface oxidation, advanced oxidation, floatability