Abstract: In order to efficiently recover the valuable metals in a refractory sulfur-oxygen mixed cop⁃ per-cobalt ores，a systematic flotation process and reagent system optimization test are carried out to solve the problem of low separation efficiency caused by complex mineral embedding，coexistence of sulfur and oxygen，and high content of high calcium and magnesium carbonate gangue.The test results show that un⁃ der the optimum test conditions of grinding fineness of -0.074 mm 63%，pH value regulator CaO dosage of 500 g/t，oxide mineral vulcanizing agent NaHS dosage of 250 g/t，combined collector SIBX + PAX dosage （100 + 300）g/t，auxiliary collector Z-200 dosage of 30 g/t and 2# oil dosage of 20 g/t，the closed-circuit test is carried out by using two roughing，one scavenging and two cleaning processes. Finally，a copper-co⁃ balt mixed concentrate with copper grade of 25.86%，cobalt grade of 0.87%，copper recovery of 89.27% and cobalt recovery of 77.22% is obtained，which can provide data support for the development and utilization of sulfur-oxygen mixed copper-cobalt ore resources.

Key words: sulfur-oxygen mixed copper-cobalt ores, sulfide flotation, sulfur-oxygen mixed flotation