Abstract: The lead grade of a lead-zinc-silver complex refractory polymetallic sulfide ore in Inner Mongolia is 4.65%，the zinc grade is 4.95%，and the silver grade is 310.92 g/t.In order to realize the effec⁃ tive separation of lead and zinc，and comprehensively recover the associated precious metal silver，the pro⁃ cess test is carried out to solve the problem of mutual encapsulation and complex embedding between the main minerals in the ore.The test results show that under the condition of grinding fineness of -0.074 mm 70%，KDYZ，zinc sulfate and sodium sulfite are used as regulators，and 25# black drug is used as collector. Lead concentrate with lead grade of 75.62%，lead recovery of 91.01%，silver content of 4 707.93 g/t and sil⁃ ver recovery of 84.14% is obtained by one roughing，three cleaning and two scavenging lead separation.The lead tailings are treated with water glass as the regulator，KDAL-02 as the zinc blende activator，KDB-01 as the collector，and zinc is separated by one roughing，three cleanings and two scavengings，the zinc con⁃ centrate with zinc grade of 55.36%，zinc recovery of 89.39%，silver content of 382.84 g/t and silver recov⁃ ery of 9.90% is obtained.

Key words: lead-zinc-silver polymetallic ore, preferential flotation, KDB-01 collector