Abstract: In order to explore efficient and environmentally friendly reagents for flotation separation of lepidolite，flotation separation of pure minerals of lepidolite，quartz and albite is studied by pure miner⁃ al flotation test，using calcium chloride as activator and FL-2 as collector.The mechanism analysis is car⁃ ried out by Zeta potential test and infrared spectroscopy. The FL-2+ Ca2+ reagent combination is applied and verified to the open-circuit and closed-circuit flotation tests of a lepidolite ore in Xinjiang. The results show that the collector FL-2 can be adsorbed on the surface of lepidolite，and the presence of Ca2+ can in⁃ crease the adsorption capacity of FL-2.After the application of FL-2+Ca2+ reagent combination，lepidolite concentrate with Li2O grade of 3.30% and Li2O recovery of 68.63% is obtained in the open-circuit flotation test of a lepidolite ore in Xinjiang，and lepidolite concentrate with Li2O grade of 3.06% and Li2O recovery of 78.22% is obtained in the closed-circuit flotation test. The product quality of the concentrate meets the index requirements.

Key words: lepidolite, Ca²⁺ , FL-2 combined collector, Zeta potential, infrared spectrum