Abstract: Since a large porphyry copper mine is put into production in 1965，its ore properties have undergone a profound evolution from easy selection to poor，fine and hybrid，and the iterative upgrading of separation technology.In order to summarize the key innovative technologies and experience in the process， aiming at the core problems such as the continuous reduction of the grade of the selected ore，the uneven distribution of the particle size，and the complex co-associated relationship in different historical stages of the mine，the evolution law of the beneficiation process flow is sorted out and analyzed.The research con⁃ tent covers the innovation of the crushing and grinding process from the traditional three sections and one closed circuit to the efficient more crushing and less grinding process，the transformation of the separation process from preferential flotation to rapid flotation-mixed step flotation and equal flotation of copper and molybdenum，as well as the long-term optimization practice of the reagent system to improve the recovery rate of copper，molybdenum and associated gold and silver.Through the induction of key innovative tech⁃ nologies，the evolution law，typical experience and lessons of the beneficiation process of the mine in or⁃ der to adapt to the change of ore properties are obtained，which can provide reference for the design，trans⁃ formation and production operation of similar large porphyry copper deposits.

Key words: large porphyry copper mine, beneficiation process, flow evolution