Abstract: In order to improve the resource utilization rate of a lead-zinc mine in Shaanxi Province， multi-element analysis，mineral technology research and flotation process parameter optimization test were carried out for the characteristics of complex mutual embedding relationship and fine particle size. The re⁃ sults show that the sphalerite in the ore is closely paragenesis with galena and pyrrhotite，which affects the quality of zinc concentrate. When the grinding fineness is -0.074 mm80%，Na₂SO₃+ZnSO₄ is used to inhib⁃ it zinc，sulfur nitrogen nine + ethyl xanthate is used as collector to select lead，copper sulfate is used to ac⁃ tivate zinc，and butyl xanthate collector is used to select zinc. The closed-circuit test can obtain excellent indexes of lead concentrate grade of 58.94%，recovery rate of 91.21%，zinc concentrate grade of 50.20%， recovery rate of 94.43%.

Key words: lead-zinc ore, finely-disseminated, preferential flotation, process parameters