Dongzhuang Gypsum Mine locates in the Sishui basin, it develops Paleogene system, and develops fully equipped with Bianqiao group, which is the second paragraph Bianqiao group for gypsum rock series. The rock assemblage of containing paste layer rock assemblage is glutenite、sandy clay and contain paste layer. It has nine cream containing layers and the relationship between the paste layer and other layers is show transition, it has no belt occurrence. The including ore seam in the mineral content is low (15%), the main ore type is gypsum, and can be divided into native gypsum and gypsum. The Dongzhuang deposit sedimented in the inland lagoon basin, as in the process of sedimentary, the water evaporating and CaSO4 concentration increasing, at the same time, the sedimentary clay class sedimenting, formed the clay rock gypsiferous deposits, which is the main ore deposit. This paper analyzes and researches the geological characteristics, ore quality and ore deposit genesis of the gypsum mine, and can provides reference and reference in the gypsum mine prospecting exploration.