Abstract: In order to study the influence of natural wind pressure on the ventilation system of Beiminghe Iron Mine, the natural wind pressure between the intake and return air shafts in winter and summer is calculated by theoretical analysis and 3D ventilation network solution software simulation,and the calculated results are analyzed and predicted.The results show that the direction of the natural wind pressure between the inlet shaft and the east air shaft in winter and summer is opposite,the natural wind pressure in winter is beneficial to mine ventilation,while the natural wind pressure in summer is not conducive to mine ventilation.During the difficult ventilation period in summer,the operation frequency of the return air main fan is increased to 47 Hz,and the total air volume of the mine is up to 188 m3/s,which can meet the design requirements of the total air volume of the safe production of the mine,effectively improve the underground production efficiency,and have certain guiding significance for the engineering practice.