Abstract: In view of the significant difference of the ore inclusions in the deep north area of Xishan in Sanshandao Gold Mine，combined with the stability analysis of surrounding rock，the ore bodies are di‐ vided into two types，hanging wall ore（thin ore body，broken ore rock，high grade）and footwall ore （thick and large ore body，good stability，low grade）. Considering the core factors such as geological con‐ ditions of ore body，stability difference of surrounding rock and grade imbalance，three mining schemes are proposed. The comparative analysis is carried out from the dimensions of mining sequence，roadway layout，preparation engineering quantity，production capacity and production management，and the pro‐ duction capacity and mining cycle of each scheme are emphatically verified. The results show that the pro‐ duction capacity of the third scheme is the best and the mining cycle is the shortest. Finally，the differen‐ tial scheme of“upward horizontal slicing filling method in footwall mine + upward drift filling method in hanging wall mine”is determined，and the independent mining preparation system is matched to realize collaborative mining，and the industrial test is carried out. The result shows that the scheme has achieved an excellent technical and economic index with a dilution rate of 5.28%，a loss rate of 5.74%，and a panel production capacity of 1 094 t/ d，which significantly improves the mining efficiency and effectively con‐ trols the mining dilution loss，providing technical reference for the mining of similar differential deposits.

Key words: collaborative mining, unbalanced grade deposits, mining method optimization