Abstract: With the rapid development of urban construction in Nanjing，Meishan mining industry has gradually been surrounded by new residential areas，and environmental problems have become increasingly prominent. Although the long-term use of xanthate in mines has the advantages of low cost and stable indica⁃ tors，the odor of xanthate is particularly obvious in summer，which has become a key factor restricting local green development. Therefore，based on the investigation of the source of odor，Meishan Mining has devel⁃ oped a new environment friendly flotation reagent with low volatility and low toxicity by means of mineral tar⁃ geted identification，quantum chemical calculation and surface spectroscopy analysis. The results show that while maintaining the original flotation index，the VOCs emission of the new reagent is significantly lower than that of the traditional xanthate，and the sulfur recovery rate of the flotation concentrate is significantly improved. Further industrial tests show that the new reagent has stable desulfurization performance and sig⁃ nificantly improves the surrounding air quality. The environmental monitoring cloud platform introduced by Meishan Mining can identify pollution trends, predict the diffusion path of pollution sources, realize dynamic assessment and over-standard warning of air quality and other indicators, and provide forward-looking deci⁃ sion support for pollution prevention and control. The research results provide a feasible path for the green substitution of traditional sulfide ore flotation reagents，which is of great significance to realize the clean pro⁃ duction and regional sustainable development of mining enterprises.

Key words: mineral targeted identification, quantum chemical calculation, volatile, environment friendly