Abstract: The lead grade of a low-grade lead-zinc ore in Hubei is 0.76%，and the zinc grade is 1.37%. The lead element mainly occurs in galena，sulfur antimony lead ore and cerussite，zinc mainly pres⁃ ents in sphalerite. Gangue minerals are mainly dolomite and quartz. The experimental conditions determined by grinding conditional test and orthogonal test were adopted. Under the conditions that the grinding fineness was -0.074 mm accounting for 75%，the lead was separated by one roughing，two cleanings and one scav⁃ enging，and the lead tailings were separated by one roughing，two cleanings and one scavenging zinc selec⁃ tion closed-circuit process test. The lead concentrate with lead grade of 45.72% and recovery rate of 80.25% and the zinc concentrate with zinc grade of 45.44% and recovery rate of 91.02% were obtained. The efficient separation of lead and zinc was realized，and qualified lead concentrate and zinc concentrate products were obtained.

Key words: lead-zinc ore, selective flotation, orthogonal test