Abstract: Aiming at the problems of low production capacity and poor operation safety caused by the unreasonable mining methods and quarry structure parameters adopted by some mines ，a typical calcite mine in southern Anhui Province was taken as an example，and based on the synergistic analysis of on-site engineering investigation，theoretical analysis，numerical simulation and other methods，the original min⁃ ing methods and quarry structure parameters adopted by the mines were optimized，and the technical and economic indexes of different mining methods were compared. The three-dimensional numerical model was constructed for the sensitivity analysis of the structural parameters of the mining field，and the following con⁃ clusions were drawn.Compared with the traditional shallow-hole mining method，the medium-deep-hole mining method of small-segmented empty field has significant advantages in terms of the degree of mechani⁃ zation，production capacity，and the safety of mining. Based on the theory of mine perimeter rock classifica⁃ tion and rock mechanics，when the width of mine room is optimized to 10 m and the width of mine pillar is optimized to 8 m，the safety coefficient of mine pillar reaches 2.27，and the overall safety is better. Through the sensitivity analysis of the structural parameters of the quarry，the adoption of Scheme 2 (mine room width of 10 m，mine pillar width of 8 m) is more reasonable in the control of quarry perimeter rock，mining efficiency，etc，which improves the production capacity and ensures the safety of the mining.The research can provide reference for the mining of similar ore bodies.

Key words: inclined very thick ore body, mining methods, stope structure, parameter optimization, safety mining