Abstract: In order to alleviate the contradiction between supply and demand of calcium-containing non-metallic minerals such as fluorite and apatite due to long-term dependence on a single type of ore， aiming at the separation problems caused by the similarity of surface active sites and the interaction of pulp ions between fluorite，apatite and calcite，dolomite and other calcium-containing gangues in co-associat⁃ ed ores，the efficient separation technology is studied.By analyzing the crystal structure and surface proper⁃ ties of fluorite，apatite and calcium-containing gangue，the research progress in the fields of differential separation process design of complex components，compound modification of traditional reagents and devel⁃ opment of new flotation reagents is systematically summarized. The applicable conditions and mechanism of various separation technologies are obtained，and it is revealed that the current technical bottlenecks main⁃ ly focuses on the regulation of mineral surface properties and selective adsorption of reagents.In the future， it shouldbe focused on the development of mineral surface directional modification technology，intelligent separation technology and environmentally friendly reagents，so as to provide theoretical basis and techni⁃ cal direction for the efficient development and utilization of co-associated calcium-containing non-metallic mineral resources.

Key words: calcium-containing minerals, non-metallic minerals, flotation reagents, process flow