Abstract: The lead grade of a lead-zinc oxide ore in Huili，Sichuan is 1.35%，the zinc grade is 7.34%，and the lead oxidation rate is 62.96%.In order to improve the recovery rate of lead and realize the comprehensive utilization of ore resources，aiming at the problems of copper，lead，zinc，sulfur，iron and other elements in the raw ore，the high oxidation rate of lead and zinc，and the difficulty in separating some oxidized ore，on the basis of the study of ore properties，the experimental research on the optimization of separation process and dosage of beneficiation reagents is carried out.The test results show that under the op‐ timum test conditions，the closed-circuit process of 3 cleaning 1 scavenging lead selection，lead selection tailings zinc floatation，zinc 2 cleaning 1 scavenging is adopted to realize the efficient separation of lead ox‐ ide，and the beneficiation index of lead oxide concentrate grade 56.54% and lead recovery rate 59.85% is obtained，which significantly improves the total recovery rate of lead.

Key words: polymetallic ore, lead oxide, process optimization, recovery rate